HLA-G

  • Official Full Name

    major histocompatibility complex, class I, G

  • Overview

    HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr

  • Synonyms

    HLA-G;major histocompatibility complex, class I, G;HLA G histocompatibility antigen, class I, G;HLA class I histocompatibility antigen, alpha chain G;b2 microglobulin;HLA G antigen;HLA class I molecule;MHC class I antigen G;HLA-G histocompatibility antigen, class I, G;MHC-G

Recombinant Proteins

  • Human
  • Cynomolgus
  • Rhesus macaque
  • HEK293
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • Insect cells
  • Yeast
  • In Vitro Cell Free System
  • Avi
  • His
  • B2M
  • GST
  • DDK
  • Myc
  • SUMO
  • Non
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-G-312H Recombinant Human HLA-G Protein, His-Avi-tagged HEK293 Human Avi&His It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide.
HLA-G-4305H Recombinant Human HLA-G protein, His-B2M-tagged E.coli Human B2M&His 25-308aa
HLA-G-1241H Recombinant Human HLA-G Protein HEK293 Human His 25-338 a.a.
HLA-G-13828H Recombinant Human HLA-G, GST-tagged E.coli Human GST 26-308a.a.
HLA-G-27H Recombinant Human HLA-G protein, GST-tagged Wheat Germ Human GST 1-338 a.a.
HLA-G-001H Active Recombinant Human HLA-G Protein, Myc/DDK-tagged HEK293 Human DDK&Myc
HLA-G-033H Recombinant Human HLA-G Protein, His-tagged E.coli Human His 26-308 aa
HLA-G-39H Recombinant Human HLA-G protein E.coli Human His&SUMO 25-338 a.a.
HLA-G-501H Active Recombinant Human HLA-G protein, His-Avi-tagged HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-505HP Active Recombinant Human HLA-G complex Protein (tetramer), His-Avi-tagged, PE-Labeled HEK293 Human Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-26H Recombinant Human HLA-G protein, MYC/DDK-tagged HEK293 Human DDK&Myc
HLA-G-38H Recombinant Human HLA-G protein E.coli Human His 25-338 a.a.
HLA-G-5493HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-G-1077H Recombinant Human HLA-G Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
HLA-G-1077H-B Recombinant Human HLA-G Protein Pre-coupled Magnetic Beads HEK293 Human
HLA-G-1718HFL Recombinant Full Length Human HLA-G Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
HLA-G-2243H Recombinant Human HLA-G Protein, His-tagged E.coli Human His Gly25-Ile308
HLA-G-2792HFL Recombinant Full Length Human HLA-G protein, Flag-tagged Mammalian Cells Human Flag Full L.
HLA-G-3036H Recombinant Human HLA-G protein, His-SUMO-tagged E.coli Human His&SUMO 25-308aa
HLA-G-3075H Recombinant Human HLA-G Protein (Met29-His117), N-GST tagged E.coli Human GST Met29-His117
HLA-G-3322H Recombinant Human HLA-G protein, His-tagged Insect cells Human His 25-319aa
HLA-G-502H Recombinant Human HLA-G protein(Gly25-Thr305(C66S)), His-Avi-tagged E.coli Human Avi&His Gly25-Thr305(C66S)
HLA-G-503C Recombinant Cynomolgus HLA-G protein, His-Avi-tagged HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-503CB Recombinant Cynomolgus HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-503H Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-504H Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-505C Recombinant Cynomolgus HLA-G Tetramer protein, His-Avi-tagged HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G)&Ile21-Met119(B2M)
HLA-G-506R Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged HEK293 Rhesus macaque Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-5426H Recombinant Human HLA-G protein Yeast Human His&SUMO 25-338 a.a.
HLA-G-651HF Recombinant Full Length Human HLA-G Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 338 amino acids

    Involved Pathway

    HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Type I diabetes mellitus HLA-F,INS,PTPRN2,HLA-DQA2,IL1A,Il2,HLA-DPA1,H2-AA,HLA-DOB,INS1
    Allograft rejection HLA-DRB3,Il2,IL10,CD28,HLA-DPA1,HLA-A,IL12B,FASLG,HLA-C,TNF
    Herpes simplex infection Ifna11,TAF5L,TAF3,MAPK9,HLA-DRB4,NFKB1,PPP1CAA,MAP3K7,SRSF4,SRSF5B
    Cell adhesion molecules (CAMs) HLA-DQA2,CDH3,NTNG1,CDH2,JAM3,NRCAM,ITGB7,ICAM2,HLA-DPB1,CLDNG
    Natural killer cell mediated cytotoxicity FAS,ULBP1,FCGR4,MAP2K1,NCR2,SHC1,VAV2,PPP3CB,FCGR3B,NCR3
    HTLV-I infection TCF3,EP300,Il2,CCND3,RELB,IL1R2,FOSL1,BAX,RB1,CDC27
    Graft-versus-host disease HLA-DQA2,KIR3DL2,HLA-DRB3,IL1B,IL1A,H2-Q10,HLA-E,HLA-F,HLA-B,HLA-DMA
    Endocytosis ADRB1,ERBB3,SH3GL1,CSF1RA,RAB4A,STAMBPB,CHMP3,SNX3,KITB,VPS25
    Viral myocarditis CD40LG,HLA-DPB1,CXADR,BID,CD86,HLA-E,SGCD,LAMA2,CCND1,SGCA

    Protein Function

    HLA-G has several biochemical functions, for example, peptide antigen binding,protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.

    Function Related Protein
    protein homodimerization activity ASNSD1,SFTPC,CCBL2,DMRTA1,TNNC1,HNF1A,STUB1,ARID3A,CUBN,DMRTA2
    peptide antigen binding MHC1ZHA,BF2,HLA-DRA,MR1,MHC1UHA,MHC1UJA,CD209,TUBB3,HLA-DQA1,CLEC4M
    receptor binding SLC9A3R2,REN,TDGF1,CAT,MCHR1,RCHY1,TNFSF14,NUDT7,MTSS1,A2M

    Interacting Protein

    HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.

    LILRB1;HLA-A

    Resources

    Gene Families

    What is immunoglobulin superfamily (IgSF)

    Research Area

    T Cell Antigen Recognition

    References

    • Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).
    • Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).

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