HLA-G
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Official Full Name
major histocompatibility complex, class I, G -
Overview
HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr -
Synonyms
HLA-G;major histocompatibility complex, class I, G;HLA G histocompatibility antigen, class I, G;HLA class I histocompatibility antigen, alpha chain G;b2 microglobulin;HLA G antigen;HLA class I molecule;MHC class I antigen G;HLA-G histocompatibility antigen, class I, G;MHC-G
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cells
- Insect cells
- Yeast
- In Vitro Cell Free System
- Avi&His
- B2M&His
- His
- GST
- DDK&Myc
- His&SUMO
- Non
- Avi&Fc&His
- Flag
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
HLA-G-312H |
Recombinant Human HLA-G Protein, His-Avi-tagged
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HEK293 | Human | Avi&His | It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide. | |
HLA-G-4305H |
Recombinant Human HLA-G protein, His-B2M-tagged
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E.coli | Human | B2M&His | 25-308aa | |
HLA-G-1241H | Recombinant Human HLA-G Protein | HEK293 | Human | His | 25-338 a.a. | |
HLA-G-13828H | Recombinant Human HLA-G, GST-tagged | E.coli | Human | GST | 26-308a.a. | |
HLA-G-27H | Recombinant Human HLA-G protein, GST-tagged | Wheat Germ | Human | GST | 1-338 a.a. | |
HLA-G-001H | Active Recombinant Human HLA-G Protein, Myc/DDK-tagged | HEK293 | Human | DDK&Myc | ||
HLA-G-033H | Recombinant Human HLA-G Protein, His-tagged | E.coli | Human | His | 26-308 aa | |
HLA-G-39H | Recombinant Human HLA-G protein | E.coli | Human | His&SUMO | 25-338 a.a. | |
HLA-G-501H |
Active Recombinant Human HLA-G protein, His-Avi-tagged
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HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
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HLA-G-505HP |
Active Recombinant Human HLA-G complex Protein (tetramer), His-Avi-tagged, PE-Labeled
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HEK293 | Human | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
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HLA-G-26H | Recombinant Human HLA-G protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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HLA-G-38H | Recombinant Human HLA-G protein | E.coli | Human | His | 25-338 a.a. |
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HLA-G-5493HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
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HLA-G-1077H | Recombinant Human HLA-G Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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HLA-G-1077H-B | Recombinant Human HLA-G Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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HLA-G-1718HFL | Recombinant Full Length Human HLA-G Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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HLA-G-2243H | Recombinant Human HLA-G Protein, His-tagged | E.coli | Human | His | Gly25-Ile308 |
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HLA-G-2792HFL | Recombinant Full Length Human HLA-G protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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HLA-G-3036H | Recombinant Human HLA-G protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 25-308aa |
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HLA-G-3075H | Recombinant Human HLA-G Protein (Met29-His117), N-GST tagged | E.coli | Human | GST | Met29-His117 |
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HLA-G-3322H | Recombinant Human HLA-G protein, His-tagged | Insect cells | Human | His | 25-319aa |
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HLA-G-502H | Recombinant Human HLA-G protein(Gly25-Thr305(C66S)), His-Avi-tagged | E.coli | Human | Avi&His | Gly25-Thr305(C66S) |
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HLA-G-503C | Recombinant Cynomolgus HLA-G protein, His-Avi-tagged | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
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HLA-G-503CB | Recombinant Cynomolgus HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
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HLA-G-503H | Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
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HLA-G-504H | Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
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HLA-G-505C | Recombinant Cynomolgus HLA-G Tetramer protein, His-Avi-tagged | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G)&Ile21-Met119(B2M) |
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HLA-G-506R | Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged | HEK293 | Rhesus macaque | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
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HLA-G-5426H | Recombinant Human HLA-G protein | Yeast | Human | His&SUMO | 25-338 a.a. |
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HLA-G-651HF | Recombinant Full Length Human HLA-G Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 338 amino acids |
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Involved Pathway
HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
HTLV-I infection | IL2RA,WNT3,WNT8A,TSPO,PDGFB,CRTC1,MAP3K1,VCAM1,PPP3R2,SLC2A1 |
Epstein-Barr virus infection | HDAC1,AKT2,TAB2,POLR2I,PSMD1,MAPK12,PRKACB,PSMD2,PSMD11,HDAC4 |
Cell adhesion molecules (CAMs) | NLGN1,HLA-DOB,CDH4,H2-AA,CLDN1,NFASCA,HLA-B,PECAM1,CD8B,ITGB8 |
Viral carcinogenesis | PKM,GTF2A1L,HIST1H2BC,IRF3,GTF2A1,MAD1L1,HDAC8,HDAC2,HIST1H4J,HIST1H4D |
Endocytosis | HRASB,SNX2,HLA-F,CBLB,CYTH1,STAM2,RAB11BA,MDM2,HRASA,SPG21 |
Herpes simplex infection | PPP1CAB,TAF5L,EEF1DB,POLR2A,Ccl12,EIF2AK4,NXF3,SRSF9,C3A.2,PTPN11B |
Type I diabetes mellitus | HLA-A,HLA-E,FAS,FASLG,H2-Q10,CD80,HLA-C,H2-AA,IL1B,IL12A |
Phagosome | ATP6V1AA,THBS4B,ATP6V1E2,TUBB,TUBB2,FCGR3B,MRC1,CTSLA,ATP6V1C1,ATP6V0A1B |
Allograft rejection | PRF1,HLA-DQA1,HLA-A,HLA-DOA,HLA-DPB1,HLA-B,IL4,IL5,IL10,HLA-E |
Protein Function
HLA-G has several biochemical functions, for example, peptide antigen binding,protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
receptor binding | HCST,DPP4,CD86,FGF13B,CXCL12,NRTN,FGF1A,WNT5B,FGF6A,TNFSF4 |
protein homodimerization activity | UXS1,GABRR1,ACTN4,PPP2R4,LRRFIP1,IKBKG,SMAD3,NPPC,PVRL3B,DMRTA1 |
peptide antigen binding | HLA-B,TUBB3,MHC1UIA,MR1,HLA-F,MHC1ZHA,HLA-E,MHC1UJA,CLEC4M,HLA-DQB1 |
Interacting Protein
HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.
LILRB1;HLA-A
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References
- Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).
- Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).